|
KMID : 0352819960110010067
|
|
Kosin Medical Journal
1996 Volume.11 No. 1 p.67 ~ p.74
|
|
|
Limbic Motor Seizures induced by Kainic Acid in Rats
|
|
|
|
|
Abstract
|
|
|
Kainic acid(KA), a powerful excitatory analogue, induces limbic motor seizures and damages the hippocampus and limbic regions in rats. This study was undertaken to observe the behavioral pattern induced by systemic administration of KA in
rats.
Twenty-three adult male Sprague-Dawley rats experienced convulsions by a single intraperitoneal injection of variable convulsive doses(20, 30, and 40mg/kg) of KA respectively. The behavioral patterns were monitored for 3 hours after
administration of KA.
Most of the rats exhibited limbic motor epileptic activity. Severe limbic convulsion and status epilepticus progressively increased with the increasing doses of KA, but the time sequence in the onset of behavioral stages induced by
administration
of variable doses of KA was not significantly different.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|